Certainly, bortezomib, a proteasome inhibitor that exerted its antileukemic actions through Notch1 downregulation, was synergistic with doxorubicin in a number of cell types of T-ALL [382] extremely. Moreover, merging anthracyclines and GSI could be beneficial to prevent stroma-dependent chemotherapy resistance. stem cell self-renewal, and differentiation based on cells and cell Continue Reading