Recent studies have shown that Grb2 mediates not only the canonical Sos/Ras pathway, associated with cell proliferation [Downward, 1994], but also Ras-independent pathways associated with morphological changes [Puto et al., 2003]. the activation of a survival pathway via Bcl-2. The effects of ErbB2 over-expression were abrogated by the humanized anti-ErbB2 Continue Reading