Since pharmacological inhibition of NMIIA filament assembly reverses axon development problems in PS/-secretase-deficient neurons, and it generally does not cause additional results in the current presence of EphA3 ICD, we conclude that PS1/-secretase/EphA3 signaling mediates axon development by promoting disassembly or preventing assembly of axonal NMIIA/actin filaments (Figure 7)

Posted on by Courtney Roberts

Since pharmacological inhibition of NMIIA filament assembly reverses axon development problems in PS/-secretase-deficient neurons, and it generally does not cause additional results in the current presence of EphA3 ICD, we conclude that PS1/-secretase/EphA3 signaling mediates axon development by promoting disassembly or preventing assembly of axonal NMIIA/actin filaments (Figure 7). The Continue Reading