Mean SEM; n=6 4-6-week old mice per group; n=7 12-16-week old mice per group; n=5 36-48-week old mice per group. Fibrinogen and fibrin fibrils initiated autophagy-dependent cell death in oligodendrocyte and pericyte cultures, whereas pharmacological and genetic manipulations of systemic fibrinogen levels in pericyte-deficient, but not control mice, influenced the Continue Reading