The signaling of LMP2A directly prevents apoptosis by activating the Ras/PI3K/AKT pathway to increase the levels of Bcl family members [20]. apoptosis, as determined by increases in Annexin-V staining, and cleavage of caspase-8, ?3 and PARP. Additional studies show that LMP2A-expressing B cell lines demonstrate a Lyn- and Syk-dependent increase Continue Reading