BCR-ABL transformation alters regulation of multiple DNA repair pathways causing genome instability (41). its native chromosomal locus for acquisition of BCR-ABL mutations and provides a new tool for further studying resistance mechanisms. Keywords:Diseases/Malignancy/Leukemia, Mutagenesis Mechanisms, Oncogene, Tyrosine Kinase, Reactive Oxygen Species (ROS), shRNA, BCR-ABL, Acquired Resistance, Chronic Myelogenous Leukemia, Imatinib Continue Reading