Disease aetiology of each brain sample is designated above each lane and the PrPSctype (using the London classification of human PrPSctypes;Collingeet al.1996; Hillet al.2003,2006) andPRNPcodon 129 genotype of the patient (M, methionine; V, valine) are designated below. and other factors may be critical modifiers of the kuru phenotype. Keywords:kuru, prion, Continue Reading