Only several quinazolinones were identified as selective COX-2 inhibitors.21?26 Open in a separate window Figure 2 Quinazoline anti-inflammatory drugs on market. Therefore, three series of 2,4,7-substituted quinazolines as potential COX-1 inhibitors were designed and synthesized. structural basis for COX-1 selectivity of two inhibitors, P6 and mofezolac (Determine ?Physique11).2 They concluded Continue Reading