1C5: follow-up visits. to PP did discriminate the dialysis population from the control group. The mean difference translated in age between the two populations was 8.4?years. The increase in MogPWV, as a function of age, was more rapid in the dialysis group. 13.3% of the dialysis patients but only 3.0% of the control group were outliers for MogPWV. The mortality rate (16 out of 143) was similar in outliers and inliers (7.4 and 8.0%/year). Stratifying patients according to MogPWV, a significant difference in survival was seen. A high parathormone (PTH) and to be dialysed for a hypertensive nephropathy were associated to a higher baseline MogPWV. Conclusions Assessing PWV on the brachial artery using a Mobil-O-Graph is a valid and simple alternative, which, in the dialysis population, is more sensitive for vascular aging than PP. As demonstrated in previous studies PWV correlates to mortality. Among specific CKD risk factors only PTH is associated with a higher baseline PWV. Trial registration ClinicalTrials.gov Identifier: “type”:”clinical-trial”,”attrs”:”text”:”NCT02327962″,”term_id”:”NCT02327962″NCT02327962. values (of the measured PWV) of less than 0.05. DPPI 1c hydrochloride To test the normality of the residuals the Shapiros test and the QQ-plot were used while the homoscedasticity was proven thanks to the Levene (for the homogeneity of the variances) and the Breusch-Pagan (for the residuals of the models) tests . To verify the absence of serial correlation of the residuals and their independence, the Durbin-Watson test was used . Hemodynamic parameters and laboratory results were compared using a t-test and a MannCWhitney U test. Contingency tables were analysed using the chi-square while the significance of the odds-ratios was explored using the two-sided Fisher’s Exact Test . In all cases, a value??0.05 was considered statistically significant. The protocol of the study was approved by the local ethics committee (Ethical Committee of the Canton Ticino, CE 2550). Informed consent was obtained from all patients prior to enrolment. Results Characteristics of the population 143 patients were DPPI 1c hydrochloride included in the dialysis group and 100 in the control group (see Table?1 for details and comparisons). Gender distribution and the DPPI 1c hydrochloride percentage of patients treated with RAAS-inhibitors and alpha-blockers were the only significant difference between groups. The presumed aetiology of ESRD in the dialysis group, in descending order, was: hypertensive nephropathy 30%, diabetic nephropathy 25%, glomerulonephritis 15%, polycystic kidney disease 12%, other identified causes 8%, obstructive or post-pyelonephritic nephropathy 6%, interstitial nephropathy 5%, unknown 3% (the aetiology of renal disease was biopsy proven in 32% of the patients only). Table 1 Characteristics of the study population (primary endpoint) Unlike Pulse Pressure (between groups on a PP against age distribution), MogPWV significantly discriminates the dialysis population from the control group ( 0.001) (Figures?1 and ?and2).2). 13.3 % (19 DPPI 1c hydrochloride out of 143) of the dialysis patients were outliers for MogPWV vs. 3.0% (3 out of 100) in the control group (0.001); signifying that 13.3% of the dialysis patients, compared to the rest of the group, had a statistically significant unexpected elevated MogPWV value. Open in a separate window Figure 1 DPPI 1c hydrochloride Pulse Pressure and age. Pulse Pressure progression as a function of age in both groups (between groups n.s.). Rabbit polyclonal to Src.This gene is highly similar to the v-src gene of Rous sarcoma virus.This proto-oncogene may play a role in the regulation of embryonic development and cell growth.The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase.Mutations in this gene could be involved in the malignant progression of colon cancer.Two transcript variants encoding the same protein have been found for this gene. Open in a separate window Figure 2 Pulse Wave Velocity and age. MogPWV progression as a function of age in both groups. Native values above (between groups n.s.); after adjusting by systolic blood pressure below (between groups 0.001). MogPWV and aging The mean horizontal difference between the two MogPWV against age distributions (depicting the behaviour of the dialysis and control group) was 8.4?years (95% CI: 3.8-12.9) meaning that the arteries of our dialysis population were, on average, 8.4?years older than controls. These findings suggest that the difference.