Normally, LX-2 cells without TGF-1 stimulation (UT) present the features of unactivated major HSCs, as observed in Figure 1C. TIMP-2 and related mobile signaling, such as for example pSmad2/3, benefit1/2, and pJNK. Amazingly, SC possesses antifibrotic activity through the suppression of TGF-1-mediated creation of collagen type 1, -SMA, as well Continue Reading