Interestingly, the levels of mutp53 appear frequently heterogenous within tumour tissues, with mutp53 over-expressing foci associated with fibrotic regions [9], suggesting that mutp53 stability may be locally influenced by tissue rigidity

Interestingly, the levels of mutp53 appear frequently heterogenous within tumour tissues, with mutp53 over-expressing foci associated with fibrotic regions [9], suggesting that mutp53 stability may be locally influenced by tissue rigidity. We reasoned that HDAC6 may promote mutp53 stabilisation downstream of mechanical inputs, transduced by RhoA-dependent cytoskeletal tension. Hsp90-mutp53 physical Continue Reading