By contrast, the MMP inhibitor BB-3103 blocked the decrease in cell surface TNF-R in PMA-stimulated cells

By contrast, the MMP inhibitor BB-3103 blocked the decrease in cell surface TNF-R in PMA-stimulated cells. with human peripheral blood monocytes. Other weak-base amines, including hydroxychloroquine, ammonium chloride and methylamine, also induced reduction of cell surface TNF receptors, whereas lysosomal proteinase inhibitor, leupeptin, and BB-3013 were without effect. Our results Continue Reading