1 difference refers to the reciprocal connection between GITR and CD28. there are CD8+ Tregs, CD3+CD4?CD8? double-negative Tregs, and CD4+ Tregs. Tregs are characterized by the manifestation of specific surface markers, some of which mediate immune suppression (Table 1). Tregs produce factors, such as IL-10, IL-35, granzyme B, and TGF-GITRmRNA Continue Reading