1). de-methylated later, and de-repressed therefore, in adult beta cells [36]. Further, Kaestner’s group [37] and Arda et al [38] described alpha and beta cell-specific open up chromatin and gene manifestation signatures utilizing a mix of assay for transposase-accessible chromatin sequencing (ATAC-seq), histone methylation marks and RNA sequencing (RNA-seq). Our Continue Reading

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