As shown in Fig.?1b, ubiquitylated Sox2 was improved following the induction markedly. COP1 and CUL4A levels upon NPCs differentiation. COP1, as the substrate receptor, interacts BNC105 with and ubiquitylates Sox2 straight, while OTUD7B gets rid of polyUb conjugates from Sox2 and raises its balance. COP1 knockdown stabilizes Sox2 and prevents Continue Reading